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KMID : 0370220050490010056
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Yakhak Hoeji
2005 Volume.49 No. 1 p.56 ~ p.59
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Acylation of Pyridazinylamines by Acyclic Anhydrides; Synthesis of N-Substituted 3-Amino-6-chloropridazines
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박은희/Park EH
박명숙/Park MS
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Abstract
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We synthesized new N-substituted 3-amino-6-chloropyridazine derivatives which were expected to retain biological activity, All synthetic process from pyridazine to 3-aminopyridazines could be carried out conveniently in high yield. N-Substituted 3-amino-6-chloropyridazine derivatives were prepared through amination and acylation from 3,6-dichlo-ropyridazine. 3-Amino-6-chloropyridazine was prepared from the reaction of 3,6-dichloropyridazine with liquid ammonia under autoclave for 6 hrs. The refluxing of 3-amino-6-chloropyridazine and the corresponding acid anhydride for 1-2 hrs afforded the N-substituted 3-amino-6-chloropyridazines. Alkyl chain of N-substituent was prolonged to six carbon (hexanoic acid).
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